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Estrogen Receptor alpha 抗体 (AA 250-300)

This anti-Estrogen Receptor alpha antibody is a 兔 多克隆 antibody detecting Estrogen Receptor alpha in WB, ELISA, IF 和 IHC (p). Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN6991887
发货至: 中国

Quick Overview for Estrogen Receptor alpha 抗体 (AA 250-300) (ABIN6991887)

抗原

See all Estrogen Receptor alpha (ESR1) 抗体
Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This Estrogen Receptor alpha antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 抗原表位

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    AA 250-300

    特异性

    ESR1 antibody is human, mouse and rat reactive.

    纯化方法

    ESR1 Antibody is affinity chromatography purified via peptide column.

    免疫原

    ESR1 antibody was raised against an 18 amino acid peptide near the center of human ESR1. The immunogen is located within amino acids 250 - 300 of ESR1.

    亚型

    IgG
  • 应用备注

    ESR1 antibody can be used for detection of ESR1 by Western blot at 1 - 2 μ,g/mL.

    Antibody validated: Western Blot in rat samples, Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    ESR1 Antibody is supplied in PBS containing 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,4 °C

    储存方法

    ESR1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
  • 抗原

    Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

    别名

    ESR1

    背景

    ESR1 Antibody: Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors (1). Estrogen receptors, including ESR1, also known as ER-alpha and ESR2 (ER-beta), contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. ESR1 is a widely expressed nuclear protein and serves as a strong activator of estrogen responsive genes (1,2). Phosphorylation of serines 104 and 106, located in the N-terminal transcription activation function-1 domain (AF-1), plays a large role in regulating ER alpha activity (3).

    分子量

    Predicted: 65 kDa

    Observed: 62 kDa

    基因ID

    2099

    NCBI登录号

    NP_001116214

    UniProt

    P03372

    途径

    Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
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